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Structural OCT examinations reported even growing defects of the Bruch's membrane. Despite the evident progression of the CE, BCVA disclosed stable values over the 5-years follow-up (1.0 LogMAR), with a worsening of metamorphopsia. Large CE may be a complication of neovascular AMD. Bruch's membrane abnormalities, including thickness and reflectivity changes, detectable on structural OCT, can be considered early biomarkers of potentially developing CE. Large CE may be a complication of neovascular AMD. Bruch's membrane abnormalities, in
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