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123 (0.758-4.532); p=0.031]. Yet, in BG group 1.729 times higher miRNA-21 expression was observed in menopause subjects (6.021±3.583) compared to pre-menopause subjects (3.500±1.517;p=0.022). Circulating miRNA-21 expression is a potential biomarker for early detection of breast cancer and might act as a breast cancer risk predictor. Key words Biomarkers, breast neoplasms, diagnosis, human plasma, miRNA-21. Circulating miRNA-21 expression is a potential biomarker for early detection of breast cancer and might act as a breast cancer risk pr