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CONCLUSION The results of our meta-analysis demonstrated diagnostic biomarkers for MSA. Furthermore, three biomarkers might be found in differential diagnosis of MSA and PD. The outcome might be great for the first diagnosis of MSA together with accuracy of MSA diagnosis.INTRODUCTION Although otolaryngology became a subspecialty just because the middle of the nineteenth century, many conditions of ENT system, their particular medical signs, universality and potential severity have now been explained since over 3000 years ago. Texts