https://www.selleckchem.com/pr....oducts/epacadostat-i
and aortic valves tissue of mice stimulated with warfarin showed increased calcium deposition and expression of osteogenic markers (ALP, BMP2, Msx2 and Runx2), and promoted p-Smad1/5 translocation from the cytoplasm to the nucleus. The addition of EGB761 significantly inhibited p-Smad1/5 translocation from the cytoplasm to the nucleus, thus suppressing calcification. In conclusion, EGB761 could ameliorate warfarin-induced aortic valve calcification through the inhibition of the BMP2-medicated Smad1/5/Runx2 signaling pathw
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