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65 requires a genome-wide association study of at least 7500 chronic migraine patients. Our results suggest that migraine chronification is caused by environmental factors rather than genetic factors. Our results suggest that migraine chronification is caused by environmental factors rather than genetic factors.Transplantation of islets in type 1 diabetes (T1D) is limited by poor islet engraftment into the liver, with two to three donor pancreases required per recipient. We aimed to condition the liver to enhance islet engraftment to i