https://www.selleckchem.com/products/cb-5083.html
Patients with relapsed pediatric solid malignancies have few therapeutic options, and many of these patients die of their disease. B7-H3 is an immune checkpoint protein encoded by the gene that is overexpressed in many pediatric cancers. Here, we investigate the activity of the B7-H3-targeting antibody-drug conjugate (ADC) m276-SL-PBD in pediatric solid malignancy patient-derived (PDX) and cell line-derived xenograft (CDX) models. B7-H3 expression was quantified by RNA sequencing and by IHC on pediatric PDX microarrays. We tested the sa
Like
Comment
Share
