https://www.selleckchem.com/pr....oducts/17-AAG(Geldan
Drug rash with eosinophilia with systemic symptoms (DRESS) is a serious adverse event associated with use of the glycopeptide antibiotic vancomycin. Vancomycin-induced DRESS is associated with the expression of HLA-A*3201, suggesting that the drug interacts with this HLA to activate CD8+ T-cells. The purpose of this study was to utilize PBMC from healthy donors to (i) investigate whether expression of HLA-A*3201 is critical for the priming naïve of T-cells with vancomycin and (ii) generate T-cell clones (TCC) to determine w
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