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In this work, the recent advances carried out in the development of nanocarriers capable of operating with immune and tumoral cells in order to orchestrate an efficient antitumoral response will be presented. The combination of nanoparticles and immunotherapy would deliver powerful weapons to the clinicians that offer safer and more efficient antitumoral treatments for the patients.Shoulder fillets are widely used in the structural optimization design of metal dampers. However, the plastic deformation property of dampers affected by stress concentration, ow