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The development of asthma and its related phenotypes is most likely due to the polymorphism of the so-called modifier genes. The goal of this study was to evaluate the polymorphic locus rs1695 of the gene association with risk factors for developing asthma and its phenotypic manifestations. This case-control study involved 164 patients with confirmed asthma diagnosis and 147 age- and sex-matched controls. Patients were divided into two groups with ( = 121) and without complications ( = 43). Among asthmatic patients, 34 manifested hyp