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The success of such applications is dependent on the effectiveness and accuracy in the action of transcription elements. The biophysical and genetic characterization associated with the paradigmatic prokaryotic repressors, LacI and TetR and the fashion designer transcription elements, transcription activator-like effector (TALE) and CRISPR-dCas9 disclosed typical axioms behind their particular effectiveness, that could aid the optimization of transcriptional activators and repressors. Add
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