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We were in a position to produce 68Ga-FOL with a high radiochemical purity and moderate molar task. Cell binding studies revealed that 68Ga-FOL had 5.1 nM affinity for FR-β. Myocardial uptake of 68Ga-FOL ended up being 20-fold lower than compared to 18F-FDG. Autoradiography and immunohistochemistry for the aorta disclosed that 68Ga-FOL radioactivity co-localized with Mac-3-positive macrophage-rich atherosclerotic plaques. The plaque-to-healthy vessel wal