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ADHD OTC Medication The majority of adults and children who use ADHD medications will experience adverse effects. They typically include weight loss or stomach upset, as well as changes in heart rate. A healthy diet and sufficient sleep can reduce the effects of these conditions. Stimulant drugs boost communication between brain cells, helping children to focus and control their impulses. can also cause an increase in blood pressure or tics. These are controlled substances that can be crushed or inhaled to create illegal substances. Methylphenidate