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Introduction Vaccination is targeted to selected adolescents and their vaccination status is little known. The purpose of this study is to assess the vaccination status and to identify factors associated with vaccination compliance in adolescents attending school in Libreville. Methods A cross sectional observational descriptive survey was conducted among students attending grades 6 at the Leon Mba high school in Libreville. Results In total, 304 students were included in the study. The average age of students was 11.60±1.20 years and s