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91, 95% CI 1.47-10.42, p = 0.006).Conclusions Annual average vitamin D levels less then 23.1 ng/mL were associated with higher all-cause mortality, regardless of the confounding variables evaluated.Although xanthinuria is nonfatal in human, xanthine oxidoreductase knockout (Xor-KO) mice have only a short lifespan. Hypoxanthine phosphoribosyltransferase activity (HPRT) in human and wild mice is higher than in laboratory mice. The aim of this study was to investigate the underlying mechanisms that give rise to the longer lifespan of high