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By applying our framework to 50 subjects of the Human Connectome Project, we reproduce 6 recently published results, devise two new models and provide a direct comparison between all mappings. Finally, we show that a glass ceiling on the performance of mappings based on eigenmodes seems to be reached and conclude with possible approaches to break this performance limit.Diagnosis of Parkinson's disease (PD) remains a challenge in clinical practice, mostly due to lack of peripheral blood markers. Transcriptomic analysis of blood samples ha