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Viable rixosome mutations that disrupt its organization with Swi6/HP1 fail to localize to heterochromatin, lead to accumulation of heterochromatic RNAs, and block spreading of H3K9me and silencing into definitely transcribed regions. These findings reveal a unique pathway for degradation of heterochromatic RNAs with essential roles in heterochromatin spreading and inheritance.We report the clinical attributes of 3 patients in France who had parotitis (swelling of this parotid salivary glands) as a c