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Furthermore, this therapy reduced the infiltration of melanoma lesions and pre-metastatic sites with PMN-MDSC that was associated with the accumulation of natural killer (NK) cells. We provide evidence for the tumor promoting properties of PMN-MDSC as well as for the anti-tumor effects upon their targeting in melanoma bearing mice. We provide evidence for the tumor-promoting properties of PMN-MDSC as well as for the anti-tumor effects upon their targeting in melanoma bearing mice. Most hemodialysis patients may experience physiological and psychological str