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How Does Medication For ADHD Work? The stimulants are the most commonly used ADHD medications prescribed. They boost the levels brain chemicals called dopamine and norepinephrine. They include amphetamines, methylphenidate and dextroamphetamines (Adderall) and lisdexafetamine (Vyvanse). Doctors typically prescribe them in long-release versions that last for six to eight hours or more. This reduces fluctuations and downs as the medicine gets rid of. This can reduce symptoms for a majority