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Possible adverse effects of the plasma were recorded during the pretreatment including associated pain, heat, erythema, and edema. The VAS score of the treated side was statistically lower (5.1±2.1) compared with the nontreated side (6.3±1.9), with a mean difference of 1.3 (95% confidence interval [CI], 0.6-1.9; P.0001). No severe adverse event was reported, and all the disturbing sensations and symptoms (pain, heat, and edema) were evaluated as mild with no mean score surpassing 4.0. Plasma pretreatment of 5minutes before topical ane
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