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This paper presents the noise optimization of a novel switched-capacitor (SC) based neural interface architecture, and its circuit demonstration in a 0.13 [Formula see text] CMOS process. To reduce thermal noise folding ratio, and suppress kT/C noise, several noise optimization techniques are developed in the proposed architecture. First, one parasitic capacitance suppression scheme is developed to block noise charge transfer from parasitic capacitors to amplifier output. Second, one recording path-splitting scheme is proposed in the inp