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anezumab responders achieved clinically meaningful improvements in all outcomes. The magnitude of improvements with fremanezumab across efficacy outcomes was far greater in responders than in the overall trial population, providing insight into expected treatment benefits in participants who respond to fremanezumab in clinical practice. ClinicalTrials.gov identifiers NCT02629861 (HALO EM) and NCT02621931 (HALO CM). ClinicalTrials.gov identifiers NCT02629861 (HALO EM) and NCT02621931 (HALO CM). Pathogenesis of Helicobacter Pylori (HP) v