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Importantly, SB203580 could reverse the effects of PAR2 agonist on the functions of chondrocytes induced with IL-1β. Taken together, the present data suggest that down-regulation of PAR2 can ameliorate OA through inducing autophagy via regulation of MAPK/NF-κB signaling pathway in vivo and in vitro, and PAR2 can be considered as a potential candidate to treat OA. © 2020 The Author(s).MOTIVATION RNA modifications play critical roles in a series of cellular and developmental processes. Knowledge about the distributions of RNA modifications