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Expected final online publication date for the Annual Review of Vision Science, Volume 6 is September 15, 2020. Please see http//www.annualreviews.org/page/journal/pubdates for revised estimates.Background Port-wine stain (PWS) is a congenital capillary malformation occurring commonly in the head and neck. Left untreated, affected areas may darken and hypertrophy over time, resulting in pronounced disfigurement, risk of spontaneous hemorrhage, and functional impairment. The burden of hypertrophic facial PWS and the benefit of laser the