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To improve the water-solubility and photodynamic antifungal task of zinc(II) phthalocyanine, two molecular-weight carboxymethyl chitosans (CMC1,50 kDa; CMC2,170 kDa) had been herein correspondingly conjugated with 1-[4-(2-aminoethyl)phenoxy] zinc(II) phthalocyanine (ZnPcN) and further quaternized, and eight book conjugates were obtained and characterized. Their photophysical and photochemical properties, cellular uptakes as well as in vitro photodynamic antifungal tasks against candidiasis are also investigated. All the co