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In parallel, drug overdose, particularly as a result of opioids, happens to be an epidemic in the us, prompting a public health crisis regarding harms associated with both recommended opioid therapy for persistent pain and illicit opioid usage. The objective of this special concern is to highlight state-of-the-art mental research that covers the mixed problems of chronic discomfort and harms connected with opioids. Articles incorporated into this unique issue focus on 2 relevant p