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Further analyses revealed that the respective medications for invasive candidiasis and Parkinson's disease were bactericidal and bacteriostatic inhibitors of S. aureus growth. Flow cytometric analysis of viability further demonstrated that caspofungin in combination with vancomycin increased MRSA cell death in an additive manner, while tolcapone appeared to suppress the bactericidal action of vancomycin. CONCLUSIONS Overall, this proof of concept study concluded that nonantibiotic drugs can alter the pharmacodynamic properties of vancomy
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