https://p450-signal.com/index.....php/cryo-em-structur
In most ovarian cancer tumors cells, cisplatin activates extracellular signal-regulated kinase1/2 (ERK1/2) signalling. Phosphoprotein enriched in astrocytes (PEA-15) is a ubiquitously expressed necessary protein, capable of sequestering ERK1/2 within the cytoplasm and suppressing cell proliferation. This as well as other functions of PEA-15 tend to be regulated by its phosphorylation standing. In this study, the relevance of PEA-15 phosphorylation state f
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