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73m in follow-up (both p 0.01), while creatinine was not. In multivariable linear regression models, a difference of the preoperative CysC level of 0.1mg/dl estimated an eGFR decline in follow-up of about 5.8ml/min/1.73m . Finally, we observed a plateau of postoperative creatinine values in the range of 1.2-1.3mg/dl, when graphically depicted vs. postoperative CysC values ('creatinine blind area'. Preoperative CysC predicts renal function impairment following RCC surgery. Furthermore, CysC might be superior to creatinine for renal f