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Pathway analysis indicated that alterations in these metabolites had been connected with cysteine and methionine metabolism, citric acid period, glycolysis and glycolic regeneration, pyruvate metabolic rate, biosynthesis of valine, leucine and isoleucine, biosynthesis of main bile acids, glycine, serine and threonine metabolic rate, caffeinated drinks metabolism, arginine and proline metabolism and phenylalanine metabolism. It r