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Magnetic Resonance Imaging (MRI) guided Radiation Therapy is a hot topic in the current studies of radiotherapy planning, which requires using MRI to generate synthetic Computed Tomography (sCT). Despite recent progress in image-to-image translation, it remains challenging to apply such techniques to generate high-quality medical images. This paper proposes a novel framework named Multi-Cycle GAN, which uses the Pseudo-Cycle Consistent module to control the consistency of generation and the domain control module to provide additional i