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82atweek 4, 8, end of treatment, and 12 weeks after treatment, respectively (all p0.01). Mean Histological Activity Index at baseline and post-treatment was 6.9±1.9 and 5.0±2.3. The METAVIR fibrosis scores improved in 61.9% of the patients. We compared patients who achieved fibrosis-regression with the non-regression group. There was no significant difference in the baseline host/virological factors between the groups. Reversal of liver inflammation and fibrosis was achieved in a significant number of patients who received direct-a
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