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The association with HLA-DRB1∗1001 was replicated in another cohort, with the meta-analysis of the discovery and replication cohorts showing that HLA-DRB1∗1001 increased the risk of immediate hypersensitivity at a genome-wide level (odds ratio, 2.96; P= 4.1×10 ). No association with HLA-DRB1∗1001 was identified in 268 patients with delayed hypersensitivity reactions to β-lactams. HLA-DRB1∗1001 predisposed to immediate hypersensitivity reactions to penicillins. Further work to identify other predisposing HLA and non-HLA loci is required. H