https://www.selleckchem.com/pr....oducts/blasticidin-s
Cyclic guanosine-3',5'-monophosphate (cGMP)-dependent protein kinase type I (cGKI aka PKG) is a major cardiac effector acting downstream of nitric oxide (NO)-sensitive soluble guanylyl cyclase (NO-GC) and natriuretic peptides (NPs), which signal through transmembrane guanylyl cyclases. Consistent with the wide distribution of the cGMP-generating guanylyl cyclases, cGKI, which usually elicits its cellular effects by direct phosphorylation of its targets, is present in multiple cardiac cell types including cardiomyocytes (CMs).
Like
Comment
Share
