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Although COPD patients tended to have relatively higher ranked means of , and than control participants, the differences were not significant. Some periodontal pathogens and respiratory pathogens were positively correlated with each other (r =0.29 to 0.47, all 0.05). The PCA graph showed that the distributions of pathogens were more dispersed but less discriminated in the COPD group than those in the control group. PLI ( = 0.045) and CAL ≥ 5mm site percentages ( = 0.01) were significantly associated with an increased risk of COPD,