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Finally, ETV induces PD-L1 in primary hepatocytes infected by HBV. These results provide evidence that ETV considerably upregulates PD-L1 on the cell surface of infected hepatocytes, which may be one of mechanisms by which infected hepatocytes subvert immune surveillance. © The Japanese Society for Immunology. 2020. All rights reserved. For permissions, please e-mail [email protected] Vitamin B12 and folate deficiency are not only linked to hematological, neurological and cardiovascular diseases, but also associate with