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12 to 0.95 ng/mL for flavonoids and ginsenosides whose recoveries were ranged from 91.93%-105.84%. We employed the response surface methodology to optimize the extraction conditions including dispersant/sample ratio, solvent concentration, and elution volume based on the content of ginsenosides as the test samples. The results showed the high extraction efficiency of ginsenosides with dispersant/sample ratio at 3/4, methanol concentration at 85 %, and elution volume at 15 mL. Taken together, we conclude that the combination strategy o