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05). Furthermore, the total number of pathogens in the incision at 2 hours into surgery was also significantly lower in the experimental group than in the control group (p less then 0.05). CONCLUSION Stringent application of the infection control pathway is an efficacious measure for improving the air cleanliness of the neurosurgery OR, decreasing the incidence rates of postoperative complications and infection, as well as controlling pathogen transmission. Copyright (c) 2020 Xin Zhang, Chunli Dong, Haozheng Yuan, Renyan Xu, Hui Zhang, Lil