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7%) compared to Group C (61.3%) (p= 0.013). Thirty-five (56.5%) patients in Group F and 25 (42.7%) patients in Group C had movement during the procedure (p = 0.24. Surgeon's satisfaction score was higher in Group F (10 [9, 10]) than Group C (9 [9, 10]) (p= 0.037). Combining low dose fentanyl with TCI propofol sedation may provide additional benefit on postoperative pain after TRUS-P biopsy, but results in perioperative hypotension. Fentanyl may attenuate patient movement during the procedure, which leads to greater surgeon's satisfa