https://www.selleckchem.com/pr....oducts/GSK429286A.ht
MTHFR knockdown reduced the blastocyst rate (P 0.01) and the numbers of total (P 0.0001), trophectoderm (P 0.0001), and inner cell mass (P 0.001) cells. The results indicate that embryonic MTHFR is indispensable for normal blastocyst development. The findings provide insight into the debatable roles of MTHFR in fertility and may be applicable for the improvement of care for early embryos via modulation of surrounding folate-related nutritional conditions in vitro and/or in utero, depending on the parental and embr
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