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5-7.0% and 7.0-7.5% groups ( = .044). The cumulative incidence rate of MACEs significantly differed among the groups ( = .046). Multivariate Cox regression analysis revealed a U-shaped relationship between 2-year HbA1c level after PCI and risk of MACEs. 2-year HbA1c 6.5% after PCI was an independent risk factor for MACEs in type 2 diabetes mellitus combined with ACS who underwent PCI ( .001). The findings indicated an increased risk of MACEs by strict glycemic control after PCI (2-year HbA1c 6.5% after PCI) in type 2 diabete