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Because of its low energy intensity, the procedure is relatively tolerable and safe, yet, more clinical studies are needed to establish its efficacy beyond currently existing strategies. Therefore, low-intensity shockwave therapy emerges as an alternative therapeutic approach that may offer a promising noninvasive intervention for treating renal diseases. Registration- URL https//www.clinicaltrials.gov; Unique identifier NCT02515461; NCT03602807; and NCT03445247.We showed that intrarenal suppression of TNF (tumor necrosis factor) produ