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Significant decrease in TNF-α and TGF-β with concomitant rise in IL-10 concentrations had been seen. Moreover, the appearance of HIF-1α, VEGF and γH2AX declined. SIGNIFICANCE 2ME2 is a promising radioprotectant with less expected complications. Is designed to unravel the root procedure of hepatic irritation during diabetes (T2DM), we established the diabetic rat model by feeding with a high fructose diet for twenty months and studied the involvement of inflammasome when you look at the liv