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Moreover, the effects of immunotherapy were good, and those of chemotherapy were poor. Overall, key genes may be involved in various complex immune regulation processes. Therefore, the quantification and verification of the BPRG score are expected to facilitate the understanding of the immunosuppressive microenvironment in BLCA and guide the choice of chemotherapeutic drugs and immunotherapeutic regimens and help predict the prognoses of patients with BLCA. Overall, key genes may be involved in various complex immune regulation processes. Therefore, the qua