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OBJECTIVES To examine whether psychological state problems, opioid use, and medication nonadherence tend to be related to inpatient and disaster department (ED) use among Medicare super-utilizers from medically underserved areas. RESEARCH DESIGN Retrospective panel research. METHODS The study included Medicare super-utilizers (≥3 hospitalizations or ≥2 hospitalizations with ≥2 ED visits in 6 months) served by a health system in a medically underserved location when