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Pluripotent cells transiently develop during peri-implantation embryogenesis and have the ability to transform into three embryonic lineages. Two typical states of pluripotency, naïve and primed, is experimentally induced in vitro. The in vitro naïve condition may be stabilized in reaction to ecological inductive cues via a unique transcriptional regulating program. But, interference with various signaling pathways creates a spectrum of alternativ