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In the last few years, significant breakthroughs were made in the isolation of iPSC and their particular differentiation, purification, and maturation into medically functional CMs. Newer little molecules are also identified to substitute the reprogramming factors for iPSC generation as well as for direct differentiation of somatic cells into CMs without an intermediary pluripotent state. This analysis provides a concise improvement on the generation of iPSC-derived CMs and their particular application