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Finding the Best ADHD Medication For Adults Stimulants, such as methylphenidate and amphetamine, (Vyvanse) are quick to regulate brain chemicals. These medications can cause loss of appetite, sleep issues and weight changes, as well as tics in certain people. Atomoxetine and some antidepressants (like bupropion) are non-stimulant medications which work slowly to aid those suffering from ADHD symptoms. They increase a chemical in the brain known as norepinephrine, which helps enhance concentr