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Using this information, we developed a real time system that defines and recognizes gestures indicating left, right, up, and down basic rotation, and zoom in, zoom out, and continuous rotation to the left and right.Consistent with a role in catalyzing rate-limiting step of protein folding, removal of genes encoding cytoplasmic protein folding catalysts belonging to the family of peptidyl-prolyl cis/trans isomerases (PPIs) in Escherichia coli confers conditional lethality. To address the molecular basis of the essentiality of PPIs, a mu