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Additionally, this isolate was more efficient in producing a biofilm on the nail surface. A partial clinical and complete mycological cure for the two patients was achieved after four months of PE daily use. Despite a complete recovery, a different outcome was observed between both cases. A more persistent onychomycosis, added to greater fungal potential to produce biofilm on the nail, seems to influence greatly the success of a topical treatment with PE. A partial clinical and complete mycological cure for the two patients was achieve