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We conduct experiments on 4 medical image segmentation datasets, and experiment results show that the proposed MSDN model outperforms multiple baselines.The incorporation of a-priori knowledge on the shape of anatomical structures and their variation through Statistical Shape Models (SSMs) has shown to be very effective in guiding highly uncertain image segmentation problems. In this paper, we construct multiple-structure SSMs of purely geometric nature, that describe the relationship between adjacent anatomical components through Cano